Application of NLRP3 Inflammasome-related Modulators in Sepsis

Sepsis is a systemic inflammatory response syndrome that caused by infection. It one of the most common critical diseases clinically. Although more anti-inflammatory drugs are available, treatment options for sepsis remain limited. The nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome multiprotein complex has been implicated in development and evolution other autoimmune diseases. activation pathway biological function NLRP3 becoming clear, regulating being explored. This article will review status various modulators might improve symptoms to provide basis further research into sepsis.